Cajun Chicken Alfredo Fettuccine

Featured in: Comfort Food Cravings

This dish features juicy chicken breasts seasoned with Cajun spices, served atop fettuccine coated in a smooth Velveeta cheese sauce. The sauce combines butter, garlic, cream, and Parmesan, enhanced with a touch of cayenne for subtle heat. Fresh parsley adds brightness, creating a rich and flavorful Southern-inspired pasta. Cooking is straightforward, with a balance of creamy texture and spicy notes, perfect for an easy, comforting meal.

Updated on Sun, 23 Nov 2025 08:01:00 GMT
Tender Cajun Chicken Alfredo Fettuccine pasta swimming in a rich, creamy Velveeta sauce, ready to serve. Save
Tender Cajun Chicken Alfredo Fettuccine pasta swimming in a rich, creamy Velveeta sauce, ready to serve. | toastytongs.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This has become a favorite family meal thanks to the rich Velveeta sauce that perfectly complements the Cajun chicken.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5 6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
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My family loved sharing this meal on cozy evenings especially when paired with a crisp green salad.

Notes

Add sautéed bell peppers or mushrooms for extra flavor and color Pair well with a chilled Chardonnay

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter) Contains wheat (fettuccine) Contains chicken Those with allergies should check ingredient labels for hidden allergens

Golden slices of Cajun Chicken Alfredo Fettuccine, nestled next to a vibrant, cheese-laden Velveeta sauce. Save
Golden slices of Cajun Chicken Alfredo Fettuccine, nestled next to a vibrant, cheese-laden Velveeta sauce. | toastytongs.com

This dish brings rich flavors and ease together for an unbeatable weeknight dinner.

Recipe FAQ

How is the Cajun seasoning applied to the chicken?

Both sides of the chicken breasts are rubbed evenly with 1 ½ tablespoons of Cajun seasoning before cooking.

What type of pasta works best for this dish?

Fettuccine pasta is recommended for its wide, flat shape that holds the creamy sauce beautifully.

How do I prevent the sauce from becoming too thick?

If the sauce thickens too much, reserved pasta water can be gradually added to loosen the texture while maintaining creaminess.

Can I adjust the heat level of the dish?

The amount of Cajun seasoning and optional cayenne pepper can be modified to increase or reduce the spicy kick.

What garnishes enhance the flavor?

Chopped fresh parsley and extra grated Parmesan cheese add freshness and depth to the final presentation.

Cajun Chicken Alfredo Fettuccine

Tender Cajun chicken paired with rich Velveeta sauce and fettuccine for a creamy comfort dish.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created By Daniel Brooks


Skill Level Easy

Heritage American (Cajun-inspired)

Output 4 Portions

Dietary considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Directions

Phase 01

Cook pasta: Bring a large pot of salted water to a boil. Cook fettuccine until al dente according to package directions. Drain, reserving ½ cup pasta water, and set aside.

Phase 02

Prepare chicken: Pat chicken breasts dry and coat both sides evenly with Cajun seasoning.

Phase 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove chicken, rest 5 minutes, then slice thinly.

Phase 04

Make sauce base: Reduce heat to medium. Add butter and garlic to the skillet; sauté for 1 minute until fragrant.

Phase 05

Add cream and cheese: Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring frequently until melted and smooth.

Phase 06

Season sauce: Incorporate Parmesan cheese, black pepper, cayenne (if using), and salt to taste. Stir until fully combined and creamy. Thin with reserved pasta water as needed.

Phase 07

Combine pasta and sauce: Toss cooked fettuccine in the sauce until thoroughly coated.

Phase 08

Serve: Divide pasta among plates. Top with sliced Cajun chicken. Garnish with chopped parsley and additional Parmesan if desired.

Tools needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy details

Review each ingredient for potential allergens and consult with a healthcare professional if you're uncertain.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter).
  • Contains wheat (fettuccine).
  • Contains poultry.

Nutritional information (per portion)

These values are approximate guidelines only and shouldn't replace professional medical guidance.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g